This locus was present as a weak linkage signal in our previous genome scan for ARMD, in the Beaver Dam Eye Study sample (D15S659, multipoint P=.047), but is otherwise novel. We have evidence of a major locus on chromosome 15q (GATA50C03 multipoint P=1.98×10 −7 empirical P≤1.0×10 −5 single-point P=3.6×10 −7). Model-free linkage analysis was performed, and tests of heterogeneity and epistasis were conducted. Fundus photographs were taken of all participating family members, and these were graded for severity by use of a quantitative scale. Family and medical history was obtained from index cases and family members. To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative disease of the retinal pigment epithelium and neurosensory retina, we conducted a genomewide scan in 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascular disease or geographic atrophy.
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